FGF9-induced proliferative response to eosinophilic inflammation in oesophagitis
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چکیده
منابع مشابه
FGF9-induced proliferative response to eosinophilic inflammation in oesophagitis
BACKGROUND Oesophagitis is characterised by basal cell hyperplasia and activated eosinophils, which release mediators including major basic protein (MBP). MBP and its mimetic polyarginine activate the calcium sensing receptor (CaSR) on oesophageal epithelium. Fibroblast growth factor 9 (FGF9) is implicated in epithelial homeostasis and proliferative response to injury, but has not been characte...
متن کاملEosinophilic oesophagitis: from physiopathology to treatment.
Eosinophilic oesophagitis is a chronic inflammatory disease characterized by eosinophilic infiltration of the oesophageal mucosa. Food and aero-allergens are involved in its pathogenesis. Dysphagia and food impaction are the dominant symptoms in adult with eosinophilic oesophagitis. However, a wide range of symptoms has been noticed such as chest pain or gastro-oesophageal reflux disease-like s...
متن کاملEosinophilic oesophagitis: a clinical update.
British Journal of General Practice, September 2012 499 BACKGROUND Eosinophilic oeosophagitis (EoE) is a clinicopathological disease typified by eosinophilic infiltrate of the oesophageal epithelium, due to an allergic inflammatory response mediated by either food antigens or aeroallergens. The presence of eosinophils in the oesophagus has been recognised for a number of years since they were d...
متن کاملEosinophilic oesophagitis: a novel treatment using Montelukast.
BACKGROUND Eosinophilic oesophagitis is a rarely diagnosed condition involving eosinophil infiltration of the oesophageal mucosa and creating significant symptoms of dysphagia. Failure to diagnose this disorder relates to reluctance to biopsy an apparently normal oesophagus. This is essential for histological diagnosis. To date, treatment success has been achieved only with corticosteroids. We ...
متن کاملThe oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis
OBJECTIVE Eosinophil predominant inflammation characterises histological features of eosinophilic oesophagitis (EoE). Endoscopy with biopsy is currently the only method to assess oesophageal mucosal inflammation in EoE. We hypothesised that measurements of luminal eosinophil-derived proteins would correlate with oesophageal mucosal inflammation in children with EoE. DESIGN The Enterotest diag...
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ژورنال
عنوان ژورنال: Gut
سال: 2008
ISSN: 0017-5749
DOI: 10.1136/gut.2008.157628